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Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis.
Alternatively 2), Wallace and De Yoreo employed parallel replica simulations for an extensive sampling of configurations, thus mimicking infinite relaxation times.[ 21] Between these extremes, we suggest 3) a simulated-annealing-type procedure to allow aggregate relaxation to a degree that both energy profiles and aggregate structures evolve continuously as functions of nucleus size.[ 16].
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Further, the ability of a crowded environment to replace ions for conserving the structure and functions of nuclei is quite typical of a growing number of observations on macromolecular assemblies, although the nucleus is probably the largest assembly for which this phenomenon has been observed.
We studied the possible role in maintaining the structure and functions of nuclei in vivo of a further but frequently overlooked property of the cytoplasm, the crowding or osmotic effects caused by diffusible macromolecules whose concentration, measured in several studies, is in the range of 130 mg/ml.
The central merit of CNT is to describe the competition of both aspects by two simple terms in order to provide an energy profile as a function of nucleus size.
Therefore, even though it is much easier to measure the biomechanical function of nucleus pulposus alone [ 19], we have established this study using bone-disc-bone specimens [ 4, 34, 35].
It is tacitly believed that the stability and functioning of nuclei in these media reflects the fact that they reproduce the ionic environment in the cytoplasm which surrounds the nucleus in vivo, but this idea is not consistent with all the available experimental evidence.
7.60 Cell Biology: Structure and Functions of the Nucleus.
The subnuclear localization of nuclear proteins is hence important for deeply understanding the construction and functions of the nucleus.
Nevertheless, the postnatal coexistence of CB and CR in the AM perikarya may indicate the cooperation of both of the proteins in some functions of the nucleus.
In this Perspective, Job Dekker et al. outline the goals and strategies of the 4D Nucleome Network, a consortium of researchers that aims to map the spatial organization and dynamics of the human and mouse genomes to gain insight into the structure and biological functions of the nucleus.
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