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TEC successfully recapitulates some major physiologic functions of native large intestine in vivo.
But because they contain only two cell types, skin substitutes cannot replace all of the functions of native human skin.
Organ printing technology was developed to allow construction of biological substitutes mimicking structures and functions of native tissues or organs.
To fulfill their promise, the fate, function, and organization of hPSCs need to be precisely regulated in a three-dimensional (3D) environment to mimic cellular structures and functions of native tissues and organs.
These technologies possess their own advantages, and the induced scaffolds are capable of partially realizing the functions of native tissue in terms of fibrous organizations, mechanical properties, and biological activities.
This work highlights the critical role of the anisotropic ECM structure for proper functions of native aortic valves and the beneficial effects of biaxial stretch for maintenance of the native ECM structure.
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The aim of this study was to characterize the function of native esophageal tissue and determine differences in functional response to stimulation between anatomical sites.
Our studies demonstrate that the transplantation of autologous mitochondria, isolated from the patient's own body, and then directly injected into the myocardial during early reperfusion augment the function of native mitochondria damaged during ischemia and enhances myocardial post-ischemic functional recovery and cellular viability.
However, many exotic plant species have become established, potentially impacting the structure and function of native plant communities.
Fiber-reinforced hydrogel composites are particularly suited for replicating the mechanical function of native fibrous tissues due to their ability to mimic the native anisotropic property distribution present.
Recombinant elastin-like polypeptide-4 (ELP4), which mimics the structure and function of native tropoelastin, represents a practical alternative to the native elastic fibre for vascular applications.
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