To this date, these low numbers and functions of lymphocytes had been adequate to provide protective immunity.
In the current study, four out of the seven immune parameters examined with the 2004 sample pertain to IFN-γ production, which may not be the best parameter, and definitely not the only parameter, for characterizing the highly diversified functions of lymphocytes.
ADA is an enzyme responsible for the degradation of adenosine and deoxyinosine molecules that inhibit the functions of lymphocytes.
Other authors have shown that the levels and functions of lymphocytes, granulocytes, Mps and natural killer cells are under the regulation of the autonomic nervous system [ 19].
Indeed, an extensive study of longitudinal cytokine profiles in RA is complicated by the influence of disease phases and/or treatments [ 14], most of which affect proportions and functions of lymphocytes and macrophages (reviewed in [ 1, 2]).
It has been suggested that only one of the many functions of lymphocytes is their participation in host immune responses since lymphoid cells as "trephocytes" also participate in a number of physiological processes aimed at maintaining homeostasis [ 2].
The Rel homology domain of p52 then forms active NF-κB dimers with RelB or other Rel proteins, which, once in the nucleus, bind a common DNA sequence motif known as the κB site and regulate the expression of genes crucial to the development and functions of lymphocytes [ 1, 2].
However, in 1984, Torres and Hart [ 4], who were interested in characterizing the role of cell-surface saccharides in the development and functions of lymphocytes, described a novel carbohydrate (GlcNAc -peptide linkaGlcNAc -peptideresent on proteins linkageed in the cytosol and the cyto- and nucleo-plasmic faces of membranous organelles.
As part of the immortalisation process, the normal cellular functions of lymphocytes are likely to be disrupted…..'......In an attempt to control one variable in the immortalisation process, we confirmed by western blot that all LCLs used were transformed by the same EBNA2A EBV strain (Lovelock et al, 2007).
Dr. Lawrence predicted many aspects of the functioning of lymphocytes and immune cells, and his work provided clues to the later discovery of immune substances known as cytokines.
