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The role of the membrane and the functions of interacting machinery during endocytosis is an area of intense current investigation, likely to yield many new insights in the coming years.
We compare the functions of interacting proteins (i) when the interaction is conserved between KSHV and VZV, and (ii) regardless of conservation.
The motif mode, i.e., the special topological combination of the molecular functions of interacting proteins, was extracted from the yeast protein interaction network and employed in the analysis of the protein interaction network at a higher resolution than ever before.
We thus hypothesise that a requirement for Plxdc2 function in vivo may be revealed in situations where the functions of interacting proteins or converging signaling pathways are perturbed.
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As underlined by Fernandez-Gimenez et al. (2012), dzud is no singular environmental event but rather a complex social-ecological phenomenon, and vulnerability to dzud is a function of interacting physical, biological, socio-economic and institutional factors.
It is shown that a proposed analytical expression accurately fits simulation data of Hagen et al. (Physica A 272 (1999) 376) for the rotational velocity autocorrelation function of interacting Brownian particles.
Epigenetic marks (histone modification and DNA methylation), transcriptional activity, and chromatin interaction appear to be correlated, and whether structure is the cause or consequence of the function of interacting regions is being actively investigated.
HSV-2 infection alters the function and phenotype of monocytes [6] [8], impeding their maturation, which may in turn alter the phenotype and function of interacting CD4+ and CD8+ T cells.
Thus, it is possible that a RING-like scaffold with a generic function of interacting with polypeptides was the ancestor of the ZZ and UBR-box.
Although algorithms for predicting the most likely (the lowest total free energy) joint structure that can be formed by two interacting RNA strands are available [see, for example, Alkan et al. (2006)], previous little work has been done for computing the partition function of interacting RNA strands.
As protein-protein interactions connect proteins that participate in either the same or different functions, networks of interacting and functionally annotated proteins can be converted into process graphs of inter-dependent function nodes (each node corresponding to interacting proteins with the same functional annotation).
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