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Several association studies have investigated genetic variants that may alter the functions of genes involved in serotonin functionality and regulation.
Many biotechnology start-ups are already working on the next task -- determining the functions of genes.
And they will use antisense technology to determine the functions of genes by turning off the genes in animals or cells, and studying what happens.
NeuralStem Biopharmaceuticals has signed an agreement with Gene Logic, a genomics company, to use the stem cells to help define the functions of genes.
Mice with deleted genes are commonly produced to study the functions of genes, by seeing what happens when the gene is missing.
But the company realizes that the same technology can also help determine the functions of genes -- by turning off a gene and seeing how this affects cells or animals.
In the case of the genetic testing the results are collated in projects like the European Mouse Mutant Archive, and the International Mouse Phenotyping Consortium IMPCC) which aim to explain and share the functions of genes in mice.
Laboratory experiments on creatures ranging from yeast to mice can reveal the functions of genes in these species.
The functions of genes and proteins are context dependent.
Gene-targeted knockout technologies are invaluable tools for understanding the functions of genes in vivo.
Functions of genes that are overexpressed in a cancer-specific manner are often involved in oncogenic processes [26]-[28 [26]-[28
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