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Other functions of eIF5A have been proposed.
The hypusinated form of eIF5A is considered to be the active form, and to date most known functions of eIF5A (such as translational elongation, RNA binding, and protein protein interactions) are wholly or partially dependent upon hypusination.
These species-specific phenotypes can be due to different functions of eIF5A(Dhp50) and eIF5A Hyp50) in single- versus multicellular organisms and might be based on conformational differences between eIF5A(Dhp50) and eIF5A Hyp50) that lead to interactions with pathways specific to phylogenetically higher organisms.
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The functions of Xrn1 in both cellular compartments are linked.
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Moreover, these three functions of Xrn1 are linked.
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"It combines the functions of MI6, the SAS and DfID," a British official quipped.
Thus, the Mmi1W112A mutant that affects Mmi1-Erh1 interaction without disrupting the termination function of Mmi1 provides a unique tool to uncouple EMC-dependent and -independent functions of Mmi1.
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