Figure 2 Distribution of the number of kinases as a function of compounds inhibiting the respective number of kinases.
Tropsha was always interested in exploring the relation between chemical structure and function of compounds and in finding a cure for diseases.
Here we report the isolation, identification and bioactivity against three parasites (Leishmania donovani, Plasmodium falciparum and Trypanosoma cruzi) and the modulation of α-glucosidase function of compounds produced by this plant, which is endemic mangrove from Central America.
Similarly, the dual function of compounds 8 or 15, as COX inhibitors and M-channel openers, may produce synergistic effects in terms of pain management.
It also considers the impact of current epigenetic research on the alcohol field and the therapeutically significant function of compounds called histone deacetylase (HDAC) inhibitors in the prevention and treatment of alcoholism.
Although the MTT and MTS assay gives quantitative data with regard to the protective function of compounds, it is very expensive and time-consuming as it is dependent on the growth rate of a particular cell line.
On the other hand, methylenation of CH2 function of compound (10) with dimethylformamide/dimethylacetal afforded benzimidazolylprop-2-enenitrile 12.
The hypothesized mechanism for the exchange is depicted in Fig. 4. The hemiketal function of compound 9 may open to give a 2,4-pyrrolidinedione, an 1,3-dicarbonyl compound that can easily exchange protons with deuterium via its enol form (the hydroxyl and carboxyl protons are also exchanged).
Figure 5 shows identification rates as a function of compound mass.
