Sentence examples for functions of atm from inspiring English sources

To study the physiological and developmental functions of ATM using the zebrafish model system, we cloned the zebrafish homolog cDNA of human ATM (hATM), zebrafish ATM (zATM), analyzed the expression pattern of zATM during early development, and further developed the system to study loss of zATM function in zebrafish embryos.

Zha, S., Sekiguchi, J., Brush, J. W., Bassing, C. H. & Alt, F. W. Complementary functions of ATM and H2AX in development and suppression of genomic instability.

Together our findings indicate that PP5 plays an essential role in the activation and checkpoint signaling functions of ATM in cells that have suffered DNA double-strand breaks.

The hundreds of radiomodulated genes identified were not a random collection, but belonged to functional pathways such as those of the cell cycle; cell death and repair; DNA replication, repair, and recombination; and transcription; translation; and signaling, indicating the strong cell reprogramming and double-strand break abrogation functions of ATM checkpoints.

Recent studies have suggested non-nuclear functions of ATM.

These results clearly illustrate novel and non-DNA damage functions of ATM in determination of cell differentiation from hematopoietic progenitors.

We hypothesize that a function of ATM is to act as a redox modulator.

It is conceivable that loss of function of Atm could increase aggressiveness at later stages of tumorigenesis.

Hence, the most studied function of ATM is its role in response to DNA damage.

This observation suggested that some other function of Atm, other than checkpoint control, was important for cellular survival following ionizing irradiation.

These results illustrate DNA damage-independent function of ATM, and indeed, that GM-CSF-activated ATM does not phosphorylate SMC1, which is a substrate of ATM when cells are exposed to DNA damage.