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IL8 (5.1-fold increase) has also been reported to have functions in the regulation of angiogenesis, cell growth and survival, leukocyte infiltration, and modification of immune responses [ 63].
Thus, both Ang-1 and Ang-2 have pivotal, but different functions in the regulation of angiogenesis depending on the quantitative balance between these factors and other angiogenic factors.
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33 Interleukin-8 biological activity in tumors and the tumor microenvironment may contribute to tumor progression through its potential function in the regulation of angiogenesis, cancer cell growth and survival, tumor cell motion, leukocyte infiltration, and modification of immune responses.
Regulation of NO production may therefore play an important role in the regulation of angiogenesis and consequently tumour progression.
In the preclinical scenario, estrogen may play a key role in the regulation of angiogenesis.
Furthermore, dolichol plays a role in the regulation of angiogenesis during tumor growth [ 24].
Cell adhesion molecules play a role in the regulation of angiogenesis.
Biologically, Chang et al (2004) have shown that one of the normal functions of COX-2 is in the regulation of angiogenesis in normal mammary tissue.
The role played by TSP-1 in the regulation of angiogenesis is not clear.
Notably, Vegf plays pivotal roles in the regulation of angiogenesis and function as a vascular permeability factor to increase microvascular permeability.
ERK1/2, one of the major targets of the MAPK signaling pathway, has been implicated in the regulation of angiogenesis for different functions including cell proliferation, migration and survival [41], [42].
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