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A large number of SSTF genes that have known functions in the establishment of the dorsal progenitor domains show higher expression levels in Lbx1 mutants (Table 2).
Seemingly, bcd and zen have specialized and perform separate functions in the establishment of the embryo's body plan [ 11- 13].
During zebra fish embryogenesis, LNX-2b functions in the establishment of the dorso-ventral axis by modulating the activity of the transcriptional repressor Bozozok [ 29, 30].
For example, canonical Wnt signaling functions in the establishment of the anterior-posterior (AP) axis; the use of posterior Wnt signaling and anterior Wnt inhibition appears to be a unifying principle of the metazoan body plan development [ 76].
Seemingly, bcd and zen have specialized and perform separate functions in the establishment of the embryo's body plan: the maternal gene bcd codes for an important morphogen that establishes anteroposterior polarity [ 20] and zen is a zygotic gene involved in dorsoventral differentiation [ 21]. zen2 has the same expression pattern of zen, although its function is unknown.
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Thus, it would be interesting to investigate the distribution of ISSsp1 in strain XLDN2-5 and its function in the establishment of the carbazole catabolic gene structure.
In this context, our study demonstrates a novel function for Wnt5a in the establishment of the dopaminergic pathways originating in the VM.
Chao, Y. C. et al. A 2.9-kilobase noncoding nuclear RNA functions in the establishment of persistent Hz-1 viral infection.
Qa-1/NKG2A interaction linked the pathogen to host immunity, and accounted for impaired NK/T functions in the establishment of HCV persistence.
Although both proteins have acetyltransferase activity, the diversity of their N-terminal domains suggests that they may perform distinct functions in the establishment of sister chromatid cohesion.
Further studies are required to unravel the molecular details of how Nup358 functions in the establishment of polarity.
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