In this century, botanical gardens effectively dropped their medicinal function in favour of scientific and aesthetic priorities, and the term "botanic garden" came to be more closely associated with the herbarium, library (and later laboratories) housed there than with the living collectionson which little research was undertaken.
At one year there was a significant improvement in social functioning in favour of doctors.
The first RCT investigated social support and physical functioning and found improved physical functioning in favour of reablement [ 8].
This included misattribution (blaming symptoms on external, short-term causes), and bargaining (ignoring deficits in functioning in favour of evidence that symptoms were normal).
In a retrospective study 24 of 173 patients treated in a single centre by an expert laparoscopic surgeon, there was a significant difference in sexual function in favour of laparoscopic compared with open surgery.
Failure to adjust for the substantially higher baseline mental health score observed in the control group would bias the effect on physical function in favour of the control group, thus masking the true effect of the intervention.
Nonetheless, we believe that the unequivocally preserved large and small fibre function in favour of near-normoglycaemia supports the notion that the degree of glycaemia governs the development of neuropathy over 24 years.
Predefined subgroup analyses revealed that patients recruited by sport physicians (n=30) did not benefit from the intervention, whereas those recruited by general practitioners (n=101) showed significant and clinically relevant differences in pain and function in favour of the intervention group.
Anyway, the authors concluded that although the overall quality was moderate, there were net benefits (pain reduction and physical function) in favour of HA compared to placebo with low risk of harm.
Comparison of such 'footprints of selection' between immune genes and genes with other functions argues in favour of pathogen-mediated selection in arthropods generally [ e.g. 8 11], and identifies the antiviral RNAi pathway as a potential coevolutionary hotspot in Drosophila [ 9,12,13].
