If a model nevertheless fails to converge after a user-specified maximum number of numerical solver parameter setting attempts, penalty functions divert the optimal search from exploring this solution region.
In so protecting itself from lightning, instead of drawing it, the rod is not as likely to fulfill its intended function of diverting lightning from other exposed objects in the vicinity.
If excessive MeCP2 disrupts neuronal function by diverting corepressors away from loci they normally repress, then abolishing methyl-CpG binding in an extra copy of MeCP2 that is still capable of interacting with corepressors (as we show in this study) would still produce the duplication phenotype in mice.
Alternatively, DCR-1 may be more often bound to the abundant miRNA precursors, and RDE-4 functions to divert DCR-1 from the processing of miRNA precursors to the processing of long dsRNA.
To the extent that those responsible for performance of this primary function are diverted from it by the necessity of trying cases, the basic fighting purpose of armies is not served.
Thus, the central tenet of our approach was that inhibition of IAP function would divert microenvironment-derived, pro-inflammatory signaling from activating pro-tumorigenic NF- κB-driven responses towards apoptosis-promoting and anti-inflammatory signaling phenotypes.
Taken together, the composition of the repeat domain is also involved in diverting the functions of both genes.
Put another way, the device functions not unlike a beltway diverting traffic around a city: Cars traveling along a linear street enter the ring road and circle partway around the city before emerging on the other side, onto another linear street.
Many viruses such as HIV-1 hijack and stimulate the host NF-κB signaling pathway as part of their life cycles, diverting NF-κB immune regulatory functions to favor viral replication.
However, this adaptation has associated metabolic costs, which includes diverting energy from normal metabolic functions to the functions that are used to cope with stress [ 31].
