One should keep in mind that both renal and hepatic functions diminish with advancing age, requiring consideration in the selection of pharmacological agents in elderly patients [ 48].
For example, T-cell functions diminish with age, as evidenced by the increased prevalence of anergy to mycobacterial and fungal skin-test antigens and the increased frequency and severity of herpes zoster infection with age.
In this type of market, not only is the gate-keeping function diminished, but the banks appear to be captive of the issuers.
Subsequently, however, the hearts of these double knockdown morphants failed to undergo looping morphogenesis, and the contractile function diminished progressively.
East/West differences in lung function diminished between 1991 and 1997.
Our experiments at the moment do not discriminate whether the phenotypes observed in mutant mice result from decreased STIP1co-chaperone function, diminished STIP1 extracellular signaling or both.
To distinguish which function diminished CHOP induction, we used PON2 point-mutations HQ or HQ, as these blunted its lactonase, but not anti-oxidative activity.
In either case, alterations in p53 function, diminished p53 protein levels and abnormal karyotypes were evident, irrespective of time or tumour model.
These observations have several clinical implications, since low testosterone concentrations may contribute to the impairment of sexual function, diminished libido, and erectile dysfunction.
This pattern has been documented in other longitudinal studies using the QLQ-C30 ; domain scores related to physical function diminished from pre-treatment to on- or immediately after treatment and emotional function improved [ 20].
