Interestingly, phosphorous-based compounds exert their functions both in the soluble and insoluble in biological systems.
A crosstalk between adipocytes and other cells in the IFP may then regulate the cellular functions both in the cartilage and the synovium and promote articular changes associated with OA.
The aim of this essay is to demonstrate, by focusing on the fibre's three axiomatic functions both in Blake's poetry and in medical writings of the Enlightenment, that Blake's sustained engagement with the fibre is far from his own idiosyncratic activity but, rather, shares a great deal with the widespread concern in Enlightenment medicine about the fibre.
Cyclin A functions both in the S and M phases of the cell cycle [ 76].
Similar circumstance holds for protein-protein interactions, which are crucial to cellular functions both in assembling protein machinery and in signaling cascades.
Phosphorylation is one of the major posttranslational modifications of tau, which contributes to fine-tuning of its physiological functions both in development and adulthood [ 161].
Despite the plethora of organs and cell types that depend on RANK function, little is known about the regulatory mechanisms that govern its functions both in normal cells and cancer cells.
One can easily predict that physical and functional interactions between the different members of the CCN family of proteins should permit fine tuning of their individual functions both in normal and pathological conditions.
IDO may exhibit its immune inhibitory functions both in the activation phases (in the draining lymph node) as well as in the effector phases (at the site of the tumor).
Their expression conservation indeed suggests that evolutionary forces act strongly on promoter regulatory regions and corresponding transcriptional regulators so that the encoded proteins achieve their functions both in a specific cell type and at a precise developmental stage.
In particular, regulatory proteins, like the transcription factors Sox9, Runx2, Osterix, Twist and Mef2c have distinct functions both in the establishment of the vertebral bodies and later in the differentiation and maturation of specific skeletal cell types (review [ 13]).
