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The STING CTD functions as a dimer and the dimerization was independent of posttranslational modifications.
In order to determine if GlLa also functions as a dimer and whether the dimerization could be inhibited by its C-terminal domain in Giardia, a 3XHA tagged GlLa C-terminal domain (aa 200 348) was over-expressed in Giardia using the Tet-inducible promoter system [30], and detected as a 21 KDa band in Western blot analysis after 24 hrs of Tet induction (Fig. 5A).
SerRS functions as a dimer in aminoacylation and the dimerization interface is mediated through the catalytic domain (CD).
The actual inhibitor of Z-ring formation is MinC, which functions as a dimer and consists of two functional domains: an N terminal domain, which is implicated in FtsZ interaction, and a C-terminal domain that interacts with MinD [22].
For GnRHR, a GPCR that regulates gonadotropin release, there is evidence that the receptor also functions as a dimer.
Since the FokI nuclease functions as a dimer, pairs of zinc-finger domains are designed to bind upstream and downstream of the cut site which increases the specificity of the complete ZFN to 24 36 nucleotides.
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The crystal structure of the HAT domain of CstF-77 revealed a dimeric association, providing the first evidence that CstF may function as a dimer.
Human La has been found to function as a dimer.
It was reported before that RecA family proteins might function as a dimer.
TSC1 and TSC2 usually function as a dimer to negatively regulate mTORC1 activity.
An example of a non-linear relationship is an inhibited activator protein that must function as a dimer.
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