Among the signal pathways listed above, the DAG-PKC signal pathway is considered to be one of the most important intracellular transduction pathways that functions as a core effect in the onset and progression of diabetic cardiomyopathy.
In the current study, NIEHS grantee William K. Kaufmann and colleagues at the University of North Carolina Chapel Hill set out to determine whether the Timeless protein may itself function as a core component of the human cell cycle.
On the assumption that NF-κB activated by PKC may function as a core effect in the cardiac hypertrophic response of diabetic cardiomyopathy, as modeled in cultured cardiomyocytes, we used PKCα/β2 inhibitor (Ro-31-8220) and NF-κB inhibitor (BAY11-7082) to study the sinhibitornsduction pathway of PKC and its downstream effect on NF-κB.
Our results clearly demonstrate that Su(H) is able to function as the core of a molecular switch, repressing transcription in the absence of Notch and activating in the presence of Notch.
Importantly RING1B is the E3 ubiquitin ligase that functions as the catalytic core of the PRC1 complex and is responsible for mono-ubiquitylation of H2A at position 119 (H2AK119ub119
Therefore, it remains to be seen whether a widely accepted "neophrenological" interpretation of the AG's function emerges with further studies or whether its function is best understood as a core component of a distributed language network.
I'm also continually drawn to Home Alone because, at its rotten core, the film functions as a study of some truly awful characters the type of anti-heroes who make Breaking Bad look like, well, Heroes.
Health systems research (HSR) is recognized as a core component of a functioning and responsive health system.
If Skype were to open its core calling functions as a service, the number of applications that would build it in would explode.
