Sentence examples for functions as a coactivator of the from inspiring English sources

CARM1 functions as a coactivator of the AR to activate target promoters containing androgen response elements, such as MMTV, PSA, and probasin [ 10, 13].

We found that in the nucleus of breast cancer cells, ErbB-2 assembles a transcriptional complex in which it functions as a coactivator of the signal transducer and activator of transcription 3 (Stot3) to promote the expression of cyclin D1 [ 8], another gene known to induce breast cancer proliferation [ 9, 10].

This phosphorylation event excludes Yki from the nucleus, where it normally functions as a coactivator for the expression of Hippo pathway target genes.

Previous reports have indicated that the CBP/p300 protein functions as a coactivator of PR [ 21, 36, 37] and cooperates with PR at the proximal Sp1-binding sites of the p21 and p27 gene promoters to increase their activities [ 19, 21].

YAP phosphorylation leads to its interaction with 14-3-3 14-3-3 14-3-3es its loss from the nucleus which it functions as a coactivator of promotes

Importantly, MUC1-C is detectable in the nucleus [25], [26] and functions as a coactivator of β-catenin-Tcf mediated transcription in cells [27].

These data demonstrate CBP/p300 functions as a coactivator of Sox9 for cartilage tissue-specific gene expression and chondrocyte differentiation.

It has recently been reported that APE1 functions as a coactivator of NRF1 and regulates mitochondrial function through an NRF1-dependent pathway.

In skeletal muscle, the transcriptional regulator PGC-1α (peroxisome-proliferator-activated receptor coactivator 1α) functions as a coactivator of YY1 in an mTOR-dependent manner, such that raptor forms a complex with YY1 and PGC-1α to bind mitochondrial gene promoters and enhance transcription.

Another member of the SMARC (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin) family has recently been shown to function as a coactivator of another member of the nuclear receptor family [100].

During fasting, PGC-1α was shown to increase expression of the FXR gene and function as a coactivator of FXR [ 59].