This is the subject of several randomized clinical trials, including the Suppression of Ovarian Function Trial (SOFT; NCT00917969).
BIG, Breast International Group CMFF, cyclophosphamide methotrexate and 5-fluorouracil; HERA, HERceptin® adjuvant; SOFT, Suppression of Ovarian Function Trial; IBCSG, International Breast Cancer Study Group.
Two new trials from the International Breast Cancer Study Group TEXTT [Tamoxifen and Exemestane Trial] and SOFT [Suppression of Ovarian Function Trial] [ 2]) will address this issue.
The Suppression of Ovarian Function Trial (SOFT: IBCSG 24-02) is designed to determine the role of OFS and the role of aromatase inhibitors for women who remain premenopausal after surgery alone or after completion of adjuvant and/or neoadjuvant chemotherapy.
In particular, the Suppression of Ovarian Function Trial (SOFT) will determine whether OA confers additional benefit in women who have received current standard chemotherapy but have not become amenorrhoeic.
The potential benefit of ovarian suppression in addition to tamoxifen for women with hormone receptor-positive breast cancer is currently under active investigation in the Suppression of Ovarian Function Trial.
BSO: bilateral salpingo-oophorectomy; CBC: contralateral breast cancer; CI: confidence interval; CMF: cyclophosphamide: methotrexate: fluorouracil; ER: estrogen receptor; LFS: Li-Fraumeni syndrome; LHRH: luteinizing releasing hormone; MRI: magnetic resonance imaging; PBM: prophylactic bilateral mastectomy; SOFT: Suppression of Ovarian Function Trial.
The frequency of use of GnRH analogues in community practice is unknown, and their role is being addressed in the multi-national intergroup Suppression of Ovarian Function Trial (SOFT).
Pop-ups frequently function as trial balloons for brick-and-mortar businesses, testing concepts with less financial risk.
Furthermore, we carried out logic function trials on the dataset to test how many times the patterns identified in the data were "True" or "False".
