In our initial study of the potential effects of cholesterol-lowering interventions on cognitive functioning, treatment with lovastatin as compared with placebo caused performance decrements on several neuropsychological tests, whereas scores on other tests were unaffected.
Secondary endpoints will be quality of life, physical functioning, treatment toxicity, treatment intensity and survival.
However, the relationship among executive functioning, treatment adherence, and glycemic control in pediatric type 1 diabetes is not well understood.
The outcome measures were the level of cancer-related knowledge, psychosocial functioning, treatment decision-making role and information needs.
The treatment effect analysis favored treatment with ivacaftor over placebo on the Body Image, Eating, Health Perceptions, Physical Functioning, Respiratory, Social Functioning, Treatment Burden, and Vitality scales.
Mean change on the Body Image, Eating Problems, Health Perceptions, Physical Functioning, Respiratory Symptoms, Social Functioning, Treatment Burden, and Vitality scales was consistently higher for ivacaftor vs. placebo.
Standardized scores were calculated for the 8 scales of the QOL-B (Physical Functioning, Role Functioning, Vitality, Social Functioning, Emotional Functioning, Treatment Burden, Health Perceptions, Respiratory Symptoms), ranging from 0 100 for each domain; higher scores indicate better HRQoL.
As secondary outcome measures, this study will also evaluate whether preservation of muscle mass may improve the clinical outcomes such as quality of life, physical functioning, treatment toxicity and progression free survival.
QOL PCD includes 48 items covering the following seven domains: Physical Functioning, Emotional Functioning, Treatment Burden, Respiratory and Sinus Symptoms, Ears and Hearing, Social Functioning, and Vitality and Health Perceptions.
The HRQOL was examined using a 52 item CF-QOL scale [ 1] across 9 domains of physical functioning, social functioning, treatment issues, chest symptoms, emotional functioning, concerns about the future, interpersonal relationships, body image and carer concerns.
70 Judicious use of insulin as an add-on therapy may improve mental health, quality of life, social functioning, treatment satisfaction, and caregiver strain in elderly diabetic patients with poor glycemic control.
