Our findings suggest to conduct QOL assessments not only event- or time-driven, but to rely on specific hypotheses on symptom and functioning trajectories.
In a secondary analysis, we investigated the symptom burden and functioning trajectories within chemotherapy lines using the time since the start of the chemotherapy line as the main effect in separate mixed linear models.
A second set of two MLMs was then run to examine whether any of the statistically significant fixed effects in the first two models interacted significantly with time in the prediction of participants' physical and mental functioning trajectories, which would indicate that these trajectories changed differentially over time as a function of one of the predictors.
We reviewed the preceding renal function trajectory (for up to 2 years prior to ESRD) for those patients meeting criteria for rapid decline in kidney function.
In CKD, several studies have shown that the assumption of only one homogeneous population in terms of renal function trajectory over time could be too strong.
We questioned whether similar patterns were evident in other CF populations, so assessed the effect of socioeconomic status on lung function trajectory measured by forced expiratory volume in 1 s (FEV1) % predicted in the Danish population.
They consist of considering a model for the renal function trajectory (usually a linear mixed model) and a model for the time-to-death or kidney replacement therapy (usually a Cox model), and linking both models using a shared latent structure.
We assessed whether boys with DMD could be grouped into classes that shared similar ambulatory function trajectories as measured by 6MWD.
Each point in both curves is determined by propagating wave function trajectories, and the minor discrepancy between the two curves is due to the use of the MCWF method.
To explore other thermodynamic parameters such as the work function, trajectories with better force values will be needed.
