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Low cytotoxicity, inhibition of cell invasion, and in vivo tolerability are desirable characteristics for anti-metastatic agents functioning through an inhibition of cathepsin L. Active members of this structurally diverse group of benzoylbenzophenone thiosemicarbazone cathepsin L inhibitors show promise as potential anti-metastatic, pre-clinical drug candidates.
Collectively, these results support the further pre-clinical development of the most active members of this structurally diverse collection of water-soluble prodrugs as promising anticancer agents functioning through a mechanism involving vascular disruption.
Rapamycin, an immunosuppressive agent which functions through a distinct mechanism, interacting with m-TOR (mammalian target of rapamycin), demonstrated a stimulatory effect on resting cells and a diminished inhibition of VEGF induced HIMEC migration compared to CsA and FK506.
An artificial body that can act only through an agent may authorize an agent to sign for it.
Principal agent theory highlights the risks of negotiating through an agent.
The long field appeared green through an agent's nightscope.
All R.E.O.'s are sold through an agent.
Agent enthusiasm is also operationalized through an agent's feedback and responses to a leaner's input.
Some landlords prefer to deal with agents or would-be tenants who come through an agent.
It's not through an agent or anything.
He did, but failed to get through to an agent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com