Furthermore, no significant increases in midline guidance errors were observed in Ncad, elmo mutants, suggesting that Ncad and Spg may function in this process independent of ELMO function.
Since USP28 was shown to be regulated by Ni ions and hypoxia, HIFs may function in this process.
For example, selective depletion of Pax6 in the OV disrupts lens placode formation (Klimova and Kozmik, 2014); however, Pax6-dependent genes that function in this process remain elusive.
These data indicate that c-Myc levels control the rate of ES cell differentiation and that c-Myc-regulated miRNAs can function in this process.
Notably, both UTH1 and YmeI are also reported to play a role in mitochondrial biogenesis but it is currently unclear how these proteins function in this process [36,37].
The findings of Borde et al (2009) emphasize the importance of histone modifications in facilitating DSB formation and open doors into an exploration of the complex and combinatorial modifications that function in this process.
More radically, ESCRT-III and VPS4 were found to be required at the inner nuclear membrane for the removal of defective nuclear pore complex (NPC) assembly intermediates, but how they might function in this process is unknown.
The multidrug and toxic compound extrusion (MATE) efflux carriers may function in this process, although the transport activities and exact roles of most of these have not yet been described [ 117].
Our data suggest that ICAM-3, a classical adhesion molecule, may also function within this process as ICAM-3-containing microparticles are significantly more potent in recruiting macrophages than their ICAM-3-deficient counterparts.
These data further confirm the induction of neurite outgrowth to be a CHC22-specific effect, that CHC22 is an essential negative regulator of sensory neuron differentiation, and that the p.E330K mutation renders CHC22 unable to function in this process.
