Although BMI may be part of the chain of events which may explain the associations between CVD risk factors and ventilatory function, the rationale to adjust for BMI was to exclude this variable as a possible explanation for the associations in the analyses carried out.
Societal complexity may create ambiguities concerning the number, function (self-rationale), and boundaries of social systems.
Dissimilar types of risk boundary would be set for different technologies, depending on their purpose, function and clinical rationale.
This mechanism is completely different from how classical ESAs function, supporting a rationale for using sotatercept as a new therapeutic agent to manage anaemia in diseases of ineffective erythropoiesis, such as β-Thalassaemia, Diamond-Blackfan Anaemia (DBA), or MDS.
The inability of monotherapies to act on the multiple pathophysiological mechanisms involved in T2DM and to maintain good glycemic control as a result of progressive deterioration of β-cell function provide the rationale for the early use of combination therapy with different classes of drugs [ 1, 13].
They get their sense and their rationale from the enterprise in which they function, and they might be inapplicable or out of place in another enterprise.
6) Identifying previously unrecognized members of the fold, if any, and thereby expanding the functional spectrum or providing a rationale for function prediction of uncharacterized members of the fold.
The results of this study, however, show that visual defects can be detected from the onset of vision in zebrafish with depleted ush1c function, thus providing a rationale for examination of Müller cell function in USH1C patients.
These findings provide a rationale why idebenone can be protective in disorders associated with impaired complex I function but normal levels of CoQ10.
National surveillance of SSIs in Norway was established with the Norwegian Surveillance System for Antibiotic Consumption and Healthcare-Associated Infections (NOIS) Act [ 2] in 2005, and we have earlier reported in detail on the rationale and functioning of this system [ 3, 4].
