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Other research has shown that there may be impaired functioning of the intestinal wall in autism (the "leaky gut" wall), and also alterations in the working of the nervous system connecting the GI system to the brain, especially involving the neurotransmitter serotonin.
The effect on ammonia is similar to that of some prebiotics (inulin), which is beneficial for the normal functioning of the intestinal epithelial cells [ 29].
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A new EU-funded project called "Crownalife" has been set up both to assess structural and functional alterations of the intestinal microflora with ageing in Europe, and to validate functional foods that promote health by improving the function of the intestinal microflora in the elderly.
These effects are mediated by changes in the composition and function of the intestinal microbiota; deleterious metabolic effects can be transferred to germ-free mice by faecal transplantation and can be abrogated by antibiotic treatment.
Many forms of diarrheal disease depend on the dysregulation of intestinal ion transporters, and an associated imbalance between secretory and absorptive functions of the intestinal epithelium.
The analysis of the molecular composition of the human intestinal microbiota indicates marked inter-individual variations which may seem paradoxical considering the high degree of conservation of major functions of the intestinal microbiota such as anaerobic digestion of alimentary fibres.
E-cadherin is required for the maintenance of architecture and function of the intestinal epithelium.
Thus, we decided to focus our investigation on the effects of CD97 overexpression on the function of the intestinal epithelium.
One of the main functions of the intestinal epithelium is to regulate the ion transport controlling the balance between absorption and secretion of fluid.
One of the most important functions of the intestinal epithelial cell layer is to form an effective barrier against the uptake of nutritional antigens, pathogens and toxins [29].
However, the role of AvrA expression on the tight junction structure and function of the intestinal epithelial cells in both in vitro and in vivo models is unexplored.
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