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But the ultimate function of the human breast becomes clear only when an infant is born and lactation begins.
They demonstrated this by studying the effects of both inducible overexpression and loss of c-Myc function on the expression of Id1 in the human breast carcinoma cell lines T47D and MCF-7, and in the mouse mammary epithelial cell line HC11.
To address the requirement of Notch on CSC function, we chose the human breast cancer cell line, MCF-7, as it has been shown to be a CSC-driven cell line by different groups [ 22, 23].
However, the carcinogenicity of PAHs on the human breast remains unclear.
Several recent studies have examined the function and evolution of a Drosophila homolog to the human breast cancer susceptibility gene BRCA2, named dmbrca2.
MUC1−/ESA+ cells have been demonstrated to function as stem cells of terminal duct lobular units in the human breast [ 15].
Detailed characterization of how the human breast functions in its normal state, and how this may be perturbed at its earliest point, will provide a critical step toward the prevention of breast cancer.
Hope springs eternal in the human breast.
In an experimental study, the subcellular localization and function of these molecules was examined by using the human breast cancer cell lines MCF7 and SK-BR-3, both of which highly express S100A14 and S100A16 proteins.
The human breast is a mysterious appendage.
These data indicated that miR-34a may suppress the function of human breast cancer cells through targeting Notch1.
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CEO of Professional Science Editing for Scientists @ prosciediting.com