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These data indicate that Hhex is required for proper functioning of the exocrine pancreas.
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They also are sufficient and necessary for the development and function of the exocrine and endocrine pancreas, respectively.
There are no indications that this procedure affects physiological function of the exocrine glands.
This then often results in chronic lung disease and insufficient function of the exocrine pancreas.
During this seminar a couple of aspects of the general reaction pattern and function of the exocrine pancreas, and the digestive function of bile is discussed.
In our model, we found Xbp1 to be decreased in the DU animals and increased in the DT animals concomitantly to the recovery of the amylase expression, a finding that stresses the important role of this gene in the correct function of the exocrine machinery.
Very pronounced is the defect in the function of the endocrine and exocrine pancreas, resulting in many systemic problems and early mortality [ 31, 129].
In patients suffering from chronic pancreatitis exocrine function is maintained for a long time even in advanced stages of the disease because the functional reserve of the exocrine pancreas is very high and symptoms of exocrine insufficiency only arise when more than 90% of the parenchyma is lost [ 30, 46].
FGF2 signaling has also been suggested to play an important role in development of the exocrine pancreas [41] and in maintenance of adult beta cell function [42].
There is a disruption of the exocrine function in subjects with smaller testicular size who failed to show a complete height catch-up growth.
Pavlov's achievement consisted in discovering an automatic neurological regulation of the exocrine functions of the stomach and the pancreas.
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