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The functioning of cartilage depends heavily on its ECM.
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Transport of solutes helps to regulate normal physiology and proper function of cartilage in diarthrodial joints.
An osteochondral interface is essential in preventing mechanical failure and maintaining normal function of cartilage.
First, the composition, structure, and function of cartilage and SF are discussed, followed by the mechanical properties of these tissues and the theoretical models that have been used to describe them.
This component is primarily responsible for the mechanical function of cartilage.
These data indicate that the nature and magnitude of shear stress may play a significant role in the homeostasis of the structure and function of cartilage.
The biological function of cartilage to provide resistance to mechanical loading is primarily attributed to its abundant extracellular matrix (ECM), mainly consisting of glycosaminoglycans (GAGs) and collagen [ 1].
We thus expect that these interactions play essential roles in the organization and mechanical function of cartilage, including electrostatic repulsion-driven elasticity, osmotic swelling, and fluid flow-independent viscoelasticity, as well as the fluid flow-induced poroelasticity.
Hysteresis in cyclic loading characterizes the viscous properties of the tissue, and is likely important to the effective functioning of articular cartilage.
The collagen network is considered highly important for cartilage function but little is known about processes that control composition and function of the cartilage collagen network in cartilage tissue engineering.
This chapter introduces the structure and function of articular cartilage, provides a brief overview of the cartilage injury and degeneration, and lists the challenges of cell-based repair.
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