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Gleevec, the drug used against GIST, was designed to destroy the functioning of a family of proteins that are uniquely hyperactive in GIST and in certain leukemias.
Another facilitator stated: …[need for more time] understanding Family Health Teams[PHT] -- how they function, not just necessary the political, the money, the administrative side of it, but the day to day functioning of a Family Health Team and the differences between them and what that looks like, and the challenges they face.
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The representative utility function of the A families is ( U_{A} = vleft( {C_{1} } right) + vleft( {C_{2} } right) + Z_{A} g(2 - S_{i} ) ).
This research has also highlighted the need to fully investigate how representative the model organism chosen to investigate the function of a family of proteins is to that of the primary organism, so as to improve the portability of the results.
We study extremal functions for a family of Poincaré Sobolev-type inequalities.
These genes are predicted to function upstream of a family of highly redundant Heat Shock transcription Factors (HSFs) which directly regulate much, but not all, HSP expression [ 20- 23].
Understanding the potential for functional overlap within a disease caused by loss-of-function of a single family member may uncover specific functions of the affected protein, as well as increase the potential for therapeutic intervention.
Very recently, OmpW from Pseudomonas fluorescens was shown to be required for the growth of this organism on naphtalene, the first direct evidence for function of a OmpW family member [18].
Our findings demonstrated in vivo a novel function of a Dock family member during demyelination in the CNS.
This finding suggests that, using Arabidopsis as the model plant, we can only learn a limited amount about the functions of a gene family.
Our study is the first to associate autophagy defects with the loss-of-function of a TIPE family member in vivo.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com