The controls exerted by mechanical forces, recognized for over a century, have been formulated as Wolff's law: "Every change in the function of a bone is followed by certain definite changes in its internal architecture and its external conformation".
The conditioning of these body parts creates a condition called, "Wolff's Law": the principle that changes in the form and function of a bone are followed by changes in its internal structure.
With this technique, modulus of elasticity (Young's modulus) is treated as a function of bone density, and bone geometry is represented by its cross-sectional area and moment of inertia.
The functioning of engineered bone tissue has depended on the osteogenic differentiation and vascularization of the seeding cells (BMSCs) [ 11].
Typically, secondary tumor formation within the bone microenvironment is considered a function of bone resorption because the degrading bone mineral matrix releases bioactive ions and growth factors critical to the proliferation of both normal and transformed cells [4], [11], [36], [37].
In this work, four different dental implant geometries were tested as a function of simulated bone density utilizing a series of artificial foam bone models (Pacific Research Laboratories, Vashon Island, WA) that vary in density and structure.
Transportation of nutrients to bone cells immersed in milieu and carrying waste of cells away is the main functioning of bone fluid.
In order to maintain normal functions of bone and calcium homeostasis, bone remodeling process is needed to be taken into account.
Vesicular trafficking is critical for the function of bone cells, exemplified by bone diseases such as osteopetrosis, which frequently results from defects in this process.
