Thus, by combining two etiologically different RA models, we succeeded in efficiently extracting genes functioning in the development of arthritis at the effector phase.
Especially genes functioning in the development of blood vessel, glial cells, epithelial cells and astrocytes clustered in the hub genes of the CNpos2 module (Additional file 4A).
For WHRadjBMI, significant pathways and gene sets included adiponectin signaling, insulin sensitivity and regulation of glucose levels, skeletal growth, transcriptional regulation and those functioning in the development of metabolically active tissues such as adipose, liver and muscle [ 62].
Despite these limitations, our prospective study contributes to the literature by emphasizing the importance of cognitive functioning in the development of functional disability and mortality in a representative population of older adults with diabetes who were free of cognitive impairment.
Several contemporary models of addiction highlight the role of impulsivity and executive functioning in the development and maintenance of addiction [1] [8].
Such transactional emotion dynamics are central theoretical elements of models of the role of parenting and family functioning in the development of problem behaviors (e.g., Patterson et al. 1992).
