Supporting this speculation, a recent report showed that miR-141 functioned in promoting cell proliferation in cancer cell lines [54].
In addition to the HER2 oncogene-dependent down-regulation of VAMP8, we discovered evidence to suggest that the HER2 oncogene-dependent up-regulation of PHGDH expression also functions in promoting insulin-independent proliferation of HER2 transformed cells.
Fn is a kind of extra-cellular matrix glycoprotein, which functions in promoting cell adhesion.
This was first suggested since the cap structure, which is recognized for decapping, also functions in promoting translation initiation by recruiting the eIF4E/ eIF4G translation initiation complex.
We wanted to determine which of the seven integrases that we had identified above as being active in promoting site-specific deletion in human cells, also functioned in promoting site-specific cassette exchange.
Tumour-associated macrophages (TAMs) are a population of macrophages in tumour microenvironment, which functions in promoting cancer cell proliferation and invasion, regulating tumour neovascularization as well as cytotoxic T-cell function.
Localized in membrane lipid rafts, T-cadherin functions in promoting survival, proliferation and migration of endothelial cells and in protecting cells from oxidative stress-induced apoptosis (Philippova et al. 2009; Joshi et al. 2005).
RANKL (receptor activator of nuclear factor κB ligand, also known as TRANCE, TNFSF11, OPGL, and ODF) is a member of the tumor necrosis factor family of signaling molecules, which functions in promoting osteoclast differentiation.
Alternatively, some studies showed that intron retention pattern is different among various tissues [ 55- 57], suggesting other factors, such as cellular environment may also function in promoting the process of intron retention.
The GHR is critical receptor for Growth Hormone (GH), which function in promoting body development and fat deposition by activating intracellular or intercellular signal transduction pathway via combining with GHR [ 25].
