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Nevertheless, the current transfection analysis demonstrates for the first time that the wmN1 and wmN2 enhancers are capable of functioning in collaboration with their native promoter not just a basal heterologous promoter to augment hPLP1 expression.
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What are the genes that function in collaboration with insulin to prolong lifespan?
However, whether the wmN1 or wmN2 region could function in collaboration with its own promoter not just a basal promoter (HSV thymidine kinase promoter)—was unknown.
Since genes function in collaboration rather than alone, subnetworks are more rational than independent responsive genes, from a biological perspective [ 34].
Further, nicotine has been shown to function in collaboration with estradiol [30].
Thus, this fact suggested that the spindle checkpoint complex may also participate in a function in collaboration with histone modification.
Thus, activation of PPARγ (mostly γ2; see also below) may over-ride Runx2 function in collaboration with other adipogenic transcription factors, such as PPARα and C/EBPs under specific conditions, resulting in conversion of particular ObL cells into adipocytes, as shown here.
MiRNAs exert their function in collaboration with various proteins in the RISC complex, such as the processing enzymes AGO2, DICER1, and TARBP2.
Taken together, our results suggest that Spt10, but not Spt21, contributes to an essential function in collaboration with Asf1 and the Hir complex, likely either in histone gene activation or an aspect of chromatin assembly.
These results demonstrate the importance of receptor collaboration during infection as opposed to receptors functioning in isolation.
Alone or in collaboration.
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