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This multipurpose functioning hypothesis is supported, for instance, by the results of Hincke et al. [ 30] and Jonchere et al. [ 31], who both showed that some egg white proteins are found also in the shell (or shell membranes).
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The model is shown to be a useful tool for testing functioning hypotheses and for hierarchizing ecophysiological processes involved in stand development.
On the other hand, the gain-of-toxic-function hypothesis might be definitely evaluated by creating an artificial prion choosing a protein target whose loss of function could be bypassed in the experimental set.
The need for cognitive functions has been proposed via the executive function hypothesis in musicians (Hannon & Trainor, 2007) and the inhibitory control model in bilinguals (Bialystok, 2009), which later gave way to a more general global cognitive model (Bialystok, 2011).
This approach is based on the Green function hypothesis and is able to accurately predict the in-plane stress field of orthotropic infinite and rectangular plate subjected to localized loading.
The mechanism(s) of prion-mediated neuronal degeneration are not fully understood but it is believed that this is caused by increased PrPSc neurotoxicity, so-called "gain of function hypothesis" as prn-p−/− mice displayed no obvious phenotype [47], or by loss of PrPC function.
Experimentation is needed to directly test the antiviral function hypothesis for NIRVs in bats.
Several appear to confirm the gain-of-function hypothesis but not all are in agreement.
In summary, our findings are not consistent with the gain-of-function hypothesis.
An alternative gain-of-function hypothesis is that PNPLA3-148M promotes formation of a signaling molecule that stimulates TG synthesis.
The abundance of pathways putatively encoding siderophores identified in this study also favours this ecological function hypothesis.
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