But unfortunately, his executive functioning challenges get in the way of his intelligence being reflected in his work or on his report card without support.
In frail elderly persons chronic conditions and loss of function challenge their autonomy.
In oral beta cell function challenge tests the dose is generally the same (e.g. 75 g in OGTT) for all adult participants.
However, failure of recent clinical trials using antioxidants in patients with cardiovascular disease, and the recent findings showing paradoxical role for NADPH oxidase-derived ROS in endothelial function challenge this long-held notion against ROS.
His innovative creations have blurred the boundaries between art and craft and form and function, challenging traditional notions of what furniture should look like and how it should be used.
Its multifunctional nature, structural complexity, diversity of isoforms, and splice variants all characterize this protein kinase and make study of its activity and function challenging.
For instance, the metabolism rate of [11C]harmine in the plasma is very high, thus making a reliable quantification of the input function challenging [8], and [11C]brofaromine has very little displaceable binding [9].
These different layers of interaction make validation of the mechanisms by which alcohol affects immune function challenging.
Given this significant amount of function-challenging mutations, the gain of an intron may compensate for a duplication simply if a proto-splice site is included.
For example, Wnt signaling ligands possess high protein sequence homology, overlapping expression domains and overlapping functions during early cardiac development which compensates for the absence of each other (Cohen et al., 2008), making the dissection of their specific functions challenging.
