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Considering the sequential EMT-MET, the preliminary hypothesis that an optimal mesenchymal may function as intermediate for efficient cell fate conversions might be more reasonable.
The remaining cells are Type III cells, sometimes referred to as "intermediate" cells.
"In normal cells," he says, "after a certain number of divisions, the cells just don't function as well".
Here, we show that progenitor cells with characteristics of intermediate/transient-amplifying cells in the luminal epithelial cell layer can function as tumor initiating cells in prostate cancer (Figure 7).
Zhang et al. (2001), demonstrated that hydrogen peroxide may function as an intermediate in ABA signalling in guard cells.
Emerging evidence has indicated that paracrine factors (such as IGF and FGF family members) that are generated in the stroma cells and induced by estrogen through ER receptors function as critical intermediate signaling molecules that stimulate epithelial proliferation.
The base functioned as an intermediate stop on the transpolar air route between North America and northern Europe, and a ballistic missile early warning station was completed in 1961.
Rare AT2s also function as alveolar stem cells.
Alternatively, it could function as an intermediate in active oxidative demethylation (Figure 1) [14].
We have also observed increases in the number of intermediate cells, considered as precursors of both Paneth and goblet cell lineages in the small intestine37,51.
Domesticated animals can also function as zoonotic intermediates (e.g., [4], [5]).
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