To test whether these genes potentially function as drivers or are simply outcomes of repeated fasting, we examined how one-time fasting affects the expression of these genes.
In this study we monitored molecular interactions of HSA21 genes that might function as drivers of dosage effects.
Changing socio-political conditions function as drivers for reforms of health professionals' education, for example by requiring inclusion of new educational objects.
A year later another group of miRs, (miR-192, -194 and −215) was identified as targets of p53 and their ability to increase the level of CDKN1A (p21CIP1) and to function as drivers of cell cycle arrest was established [ 17].
Myc and NF-κB are well-established master regulators of initiation of transcriptional programs, but when deregulated, they function as oncogenic drivers in B cell lymphomas.
Car-calling apps like Uber and Indian competitors Ola and TaxiForSure have opposed the scheme because it requires them to own taxis instead of just functioning as a marketplace for drivers and passengers, and therefore costs more money.
Technological change – Romer demonstrates how knowledge can function as a driver of long-term economic growth.
His work has focused on confronting the rapid pace of technological change by showing how knowledge can function as a driver of long-term economic growth.
Conversely, an amplified or deleted gene that is upregulated or downregulated only minimally, in a statistically non-significant manner in patient data can still function as a driver gene if it alters the expression of its network neighbourhood.
The elevated infiltration of the adipose tissue with immune cells seems to function as the driver for the emergence of defects in insulin signaling, ie, insulin resistance; increase in adipocyte number and size, ie, obesity; and plaque destabilization and rupture, ie, atherogenesis.
DOI: http://dx.doi.org/10.7554/eLife.00999.008 Previous studies implicated that the Hpo pathway effector Yki functions as a driver of proliferation in both ECs and ISCs and damage-induced ISC proliferation via both cell-autonomous and non-cell-autonomous mechanisms (Karpowicz et al., 2010; Ren et al., 2010; Shaw et al., 2010).
