Sentence examples for functioning as an integrator from inspiring English sources

Mouse models have raised the possibility that PAI-1 is not merely a product of obesity, but has a causal role in obesity and insulin resistance, as PAI-1 inhibition has the potential to reduce obesity and improve insulin sensitivity [ 39, 40], possibly via PAI-1 functioning as an integrator of cell signalling [ 41].

Therefore, Cic functions as an integrator of upstream signals that are essential for tissue patterning and organ growth.

We speculate that FICD has thus features of an enzymatic sensor of Ca2+ in the ER that could allow it to function as an integrator between Ca2+ homeostasis in the ER and the BiP-mediated UPR.

Itch can function as an integrator for pJNK.

Likewise the LSD1 protein probably functions as an integrator of chloroplast-derived redox signals to regulate programmed cell death in response to excess light [49].

The CHOP-mediated death signal is finally transmitted to the mitochondria, which functions as an integrator and amplifier of the death pathway but the other mechanistic details of CHOP action are still unclear [57].

Furthermore, it concords with the notion that the mammalian target of rapamycin complex 1 (mTORC1) functions as an integrator of cell growth signals (reviewed in [27]) through its downstream targets, S6K1 and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) [28, [28].

LRP1 may function as an integrator of proliferative and anti-proliferative signals that control physiological mechanisms common to the pathogenesis of Marfan syndrome and atherosclerosis, and this is essential for maintaining vascular wall integrity.

ERFs are a control point for crosstalk with other signals and they function as an integrator of the ethylene and jasmonic acid pathway [ 21].

It functions as an integrator of physiological and environmental cues to implement a specific transcriptional programme, of which NRF (nuclear respiratory factor -1 and -2 are key transcriptional regulators co-ordinating expression ofactor -1 nucleandencoded subunits of the respiratory complexes and mitochondrial transcription factors (reviewed by Scarpulla, 2008).

The vanilloid receptor 1 (VR1) is expressed by the type II A-delta and C-fiber neurons, functioning as a molecular integrator for nociception.