For ABC transporters, such a charge-induced conformational change may function as a trigger for releasing ΔGE, by lowering the transition-state energy barrier from CIn to COut.
This mechanism may be relevant to cocaine abuse in the context of extracellular matrix remodeling, in that a cocaine induced reset of pacemaker activity might be an underlying activity dependent metaplasticity that functions as a trigger for the consolidation or adaptive generalization of memories of an intense euphoria.
Thus, poor school achievement might function as a trigger for alterations in the causal pathway of genetic and environmental factors underlying neurobiological changes leading to mental disorders.
Collectively, these results emphasize that reversible phosphorylation may function as a trigger to induce or disrupt α-helix, depending on the position of the phosphorylation site within an α-helix.
While RBC necroptosis shared many molecular steps with canonical necroptosis pathways, it was distinct from eryptosis, a RBC-specific programmed cell death (PCD) that functions as a trigger for RBC clearance by macrophages.
The observation of an internal substrate binding site by X-ray crystallography has also helped to resolve the paradox since it suggests that substrate binding may function as a trigger for the switch from globin to peroxidase function by its strong interaction with the heme Fe.
Thus, rafts behave as recruitment platforms to facilitate and potentiate downstream signaling events, with Fas functioning as a critical trigger of the apoptotic process.
This layered organization appears to be consistent with the fact that the ROS-mediated regulon is an ' early response' mechanism that may be functioning as an initial trigger to a more complex transcriptional network involved in cellular defenses against the physiological injuries caused by chilling.
Under the correct circumstances, these positive feedback loops could function as a bistable trigger for mitosis, and oscillators with bistable triggers may be particularly relevant to biological applications such as cell cycle regulation.
The system functions as a mitotic trigger, toggling between a stable interphase state, where CDK1 is off, and a stable M-phase state, where CDK1 is on.
This result supports the idea that Clu function is necessary to keep the PINK1-Park interaction from being triggered, thus effectively functioning as a negative regulator.
