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The positive charge and the cytosolic, membrane-proximal location of this sequence are reminiscent of the RHRRR sequence that functions as a raft localization marker for the CD4 receptor.
As aPPD is structurally more similar to cholesterol, it would not be surprising if it functions as a stronger raft disruptor through intercalating itself into the lipid rafts to cause changes in the microenvironment of the membrane, which in turn results in an alteration of the protein composition of the lipid rafts.
LRE encodes a putative plant-specific GPI-anchor protein (GAP), a eukaryotic protein that functions as a lipid raft in cell-cell signalling.
Thus, rafts behave as recruitment platforms to facilitate and potentiate downstream signaling events, with Fas functioning as a critical trigger of the apoptotic process.
In addition for specific functions such as anchoring or tethering myosin VI may operate as a monomer, whereas in trafficking pathways it may function as a dimer or as raft of monomers.
Cholesterol is believed to serve as a spacer between the hydrocarbon chains of sphiongolipids and to function as a dynamic glue that keeps the raft assembly together.
TRPC1 has been associated with cholesterol-containing caveolae and lipid rafts [52] and suggested to function as a component of store-operated channels only when linked to STIM1 in lipid rafts [50].
Seladin-1 was found to be identical to the gene DHCR24, which functions as a key enzyme in cholesterol biosynthesis and lipid raft formation [ 9, 10].
TRPC1 has been associated with cholesterol-containing caveolae and other lipid rafts (Lockwich et al. 2000) and suggested to function as a component of store-operated channels only when linked to stromal interaction molecule-1 (STin1) in lipid rafts (Alicia et al. 2008).
The network functions as a time bank.
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