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In particular the presence of plekstrin homology (PH) and Ras-binding domains (RBD) makes Tiam1 a good candidate for linking PI3K and/or Ras to Rac1 in response to NGF, functioning as a mediator of neuronal differentiation.
Thus, Wip1 inhibits UV-induced phosphorylation of p53 on Ser33 and Ser46 via p38 downregulation, functioning as a mediator in a p53 negative feedback regulatory loop.
We speculate that the disappearance of the lncRNA-mRNA crosstalk noticed in cancer may occur because the miRNA stops functioning as a mediator of their interaction, with a consequent break-up in the ceRNA relationship.
It is, therefore, possible that current symptoms of depression might have influenced ratings of cognitive reactivity, or neuroticism could have influenced both ratings of depression and cognitive reactivity without cognitive reactivity necessarily functioning as a mediator of the relation between neuroticism and depressive symptoms.
Increases in T cell numbers occurred in all compartments analyzed, consistent with IL-7 functioning as a mediator of homeostatic proliferation.
Cyclophilin A, is also well recognized as a secreted growth factor that is induced by oxidative stress [ 2] functioning as a mediator of tissue damage associated with inflammation and oxidative stress [ 3].
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Examination of various extended models served to confirm that emotional symptoms do not function as a mediator of the relationship between sleep problems and functional disability, even if physical symptoms are removed from the model.
President Eduard Shevardnadze of Georgia might be someone who could function as a mediator.
NO2 was electrochemically reduced to H2O and NO that functioned as a mediator over the graphite-cathode.
The AC functions as a mediator of redox equivalents between the external reductant and the internal sorbate.
There is growing evidence that nerve growth factor (NGF) may function as a mediator of persistent pain states.
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