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ThPOK, the critical transcription factor for differentiation of the helper T cell lineage in the thymus, continues to function as a gatekeeper to maintain helper T cell identity by repressing the transcription factor Runx3 in mature T cells.
Therefore, our results further confirm the potential of PstS1 to function as a potent inducer of T-helper 1 and cell-mediated immune responses.
9 Here we have implicitly assumed K−L≥1 such that at least one helper node will function as a relay.
IFN- γ is a major product of activated T helper cells that can function as a pro- or antiresorptive cytokine.
"We function as a nonprofit.
Our group previously showed that Th17 cells function as osteoclastogenic helper T cells in bone destruction associated with inflammation, and that inhibition of Th17 development has the potential of a beneficial impact on bone diseases including rheumatoid arthritis (RA) [ 1].
It has not been established if there is any immune response that is strictly dependent on Th9 cells, or if IL-9-secreting T cells function in vivo as a helper cell of T helper cells.
Some have argued that training community individuals to deliver health information destroys their ability to function as natural helpers [ 17].
We identified novel CD4 T-cell EGFR epitopes and amongst these, EGFR875 889 functions as a promiscuous helper T-cell epitope that can elicit effective antitumour T-cell responses against tumours expressing HER family members and c-MET.
It is interesting that, at least in mice, Th17 lymphocytes can also function as B-cell helpers [ 32].
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