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This soluble protein, although produced in the salivary glands only, can migrate through the entire intestinal tract thus functioning as a general activator of the intestinal immune response.
We have observed that tamoxifen mainly enhances the binding of PAX2 at genome-wide level (Gilfillan et al. 2012), which suggests that PAX2 might be functioning as a general repressor for ER tamoxifen action (Fig. 3).
E-P formation is assisted by a conserved aspartic acid (D425 in SHP2) in the WPD-loop, functioning as a general acid, to neutralize the buildup of a negative charge on the leaving group.
We expressed soluble NcGRA2 and NcSRS2 by fusing them with MBP, which is capable of functioning as a general molecular chaperone in the context of a fusion protein [ 28].
Importantly, the linking of nSMase2 expression to both ATR and Chk1 suggests that nSMase2 induction by p53 may occur in very specific cellular contexts, rather than functioning as a general effector of DNA damage.
One possibility is that a conserved histidine in the trigger loop (His1085 in Pol II, His936 in E. coli RNAP, and His1242 in T. aquaticus RNAP) might couple substrate recognition to catalysis by functioning as a general acid [ 5].
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The NCAA functions as a general legislative and administrative authority for men's and women's intercollegiate athletics.
Previous computational designs have incorporated a water molecule to facilitate formation and breakdown of the carbinolamine intermediate to give the Schiff base and to function as a general acid/base.
His argument is not exactly clear, but the problem appears to be semantic: he cannot find an interpretation of the phrase 'itself to be true [se esse veram]' in the supplementary condition that will permit it to function as a general principle.
He's also had success on websites such as Large Penis Support Group (LPSG), 7OrBetter and Size Minded, which were all designed with hung men in mind (LPSG also functions as a general forum for all large penis related matters).
The house of life also functioned as a general center of learning, containing works on non-religious subjects such as history, geography, astronomy, and medicine.
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