In conclusion, our findings suggest that PC1 may function as a controller of Ca2+ release in response to extracellular stimuli also through the NCCE pathway, thus regulating the Ca2+-mediated signal transduction involved in cell proliferation through the NFAT pathway.
The target of rapamycin (TOR) is a large (281 kDa) conserved Ser/Thr protein kinase that functions as a central controller of cell growth.
The mTOR is a member of serine/threonine protein kinase family that functions as a central controller of growth, proliferation, metabolism and angiogenesis, but its signaling is dysregulated in various human diseases especially in certain solid tumors including the glioblastoma.
Due to the bifunctional roles in catabolic and anabolic metabolism, ACC functions as a bioenergetics controller to promote stem cell function and tissue regeneration to regulate lipid homeostasis (Folmes et al. 2013; Fullerton et al. 2013; Knobloch et al. 2013; Park et al. 2013).
As the outputs of the global controller are binary, this controller functions as a binary control.
OHR2-dependent HAN output increased linearly during constant OHN input, suggesting that the OHN→HANOHR2 module may function as an integral controller.
Conversely, OHR2-dependent operation (i.e., linear increase in output during constant input) may function as an integral controller whose output is proportional to integrated input (DiStefano et al., 2012).
You know how there's universal remote controls (like this one I used), smart devices that can control a TV, cable box, DVD player, etc.? It's the same principle here: a single device that's about to function as a video game controller for all sorts of consoles.
As revealed from our between the processes of transcription and secretion, NF90 functions as a post-transcriptional controller of the fate of SASP mRNAs.
The BG have been implicated in motor control and cognitive switching tasks; in particular, it is believed that the BG function as a controller for motor tasks by selectively disinhibiting appropriate portions of the thalamus and hence activating, via a feedback loop, cortical regions.
