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To better characterize to what extent viral proteins affect the functioning and the robustness of the cellular network, we next analyzed topological properties of targeted proteins within HIN (see Additional file 1 for accurate description of topological properties).
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Previous work has addressed this problem by modelling the potential values of uncertain parameters as probability distribution functions, and estimating the robustness of the system using Monte Carlo-based methods.
The ApEn in Zweeloo woman was higher thus her ANS was functioning well and reflected the robustness of her ANS function consistent also with sympathetic activation.
Meetings were held regularly to allow discussion about the function of interviewing and the robustness of the data collected.
Recent research has shown that several key mammalian signaling systems such as ERK, NF-κB, N-FAT/Crz1, Stat/Smad/Hes1 and p53 have dynamic oscillatory or cyclic behavior (5a, 30, 42, 49a, 71) leading to the hypothesis that the temporal profile of the signal is either encoding important information or functioning to enhance the robustness of the response.
As a result, highly reproducible results were observed in both the PFAA profiles and the discriminating performance of previously obtained PFAA-based, multiplex discriminant functions, suggesting the robustness of PFAA profiling for the early detection of lung cancer.
In this vein, recent theoretical and experimental work has focused on elucidating the relationships between the multi-loop architectures characteristic of circadian systems, the flexibility of the clock's dynamic behaviour and the robustness of its function in biological timing [ 3- 9].
Through the complementary sensitivity function analysis, the robustness of the polynomial-based m-IPD controller design is found to depend on the term of while the characteristic ratio assignment and the time constant determine the nominal time response of the close-loop control system.
The paucity of isoform selective kinase inhibitors or CNS penetrant kinase inhibitors with in vivo function make the robustness of data evaluation even more critical.
In an earlier study, we demonstrated that the performance and the robustness of FE-RBM function approximation can be improved by scaling the free energy by a constant that is related to the size of network.
A change of chromatographic column led to changes in absolute peak areas but not in the peak area ratios and related calibration functions, which confirms the robustness of the analytical method.
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