Blocking of Rab4 and Rab11 function simultaneously caused a loss of Fmi at junctions; however, it also affected the trafficking of other junctional proteins such as E-cadherin, and so the effects on Fmi may be indirect.
The p.T42M missense mutation does not influence transcript or protein expression, but acid-ceramidase activity is reduced to ∼30%, hinting at a loss-of-enzymatic-function mechanism (Zhou et al., 2012).
We provide the first such guarantees, showing that Stochastic Gradient Descent with AdaGrad converges to a near-stationary point of a smooth loss function, at a rate which nearly matches the "oracle" rate as if the curvature of the loss function and noise level on the stochastic gradients were known in advance.
In addition to a loss function at the sentence level, a probabilistic model is used to define a distribution for the loss at the frame level.
This indicates a gain of function process in terms of susceptibility rather than a loss of function phenomena, at least for certain hippocampal cells, since in KA-treated Prnp −/− hippocampus such cells are healthy.
Patients in the placebo arm of the study experienced a loss of motor function at a similar rate to that previously reported (Vuillerot et al. 2013).
Mutations leading to a loss of function at this gene cause autosomal dominant polycystic kidney disease in both humans [ 29] and mouse models [ 30].
The underlying selection strategy relies on the choice of a loss function, which aims at evaluating the gap between the actual and the predicted outcomes for each candidate.
Mutant mitochondrial tRNAs frequently induce various loss-of-function at a molecular level [ 2] including not only damaged mitochondrial protein synthesis, but also inhibited aminoacylation [ 3], tRNA molecular instability [ 4], altered tRNA processing [ 5], wobble-base modification deficiency [ 6, 7], or a combination of these.
Therefore, progressive truncation of the N-terminus resulted in a stepwise decrease and not in a sharp loss of expression and function at a single site of protein sequence.
Cocaine mediates its reinforcing and toxic actions through a "loss of function" effect at multiple receptors.
