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It is possible that regulatory sequences of Slc10a3, such as RNA-binding protein cognate sites in the 5'UTR, are functionally united with the Ubl4 ORF by this intergenic splicing and may result in Slc10a3 sequence-mediated effects on Ubl4 mRNA or protein levels.
Given the similarities between the MORCs and paraMORCs from RM systems on one hand and MutL in MMR and VSR on the other, it appears likely that these systems arose early in bacterial evolution from an ancestral version that functionally united GHKL ATPases, nucleases and helicases.
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