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Functionally, time-lapse assays revealed that SV transport was severely impaired in axonal processes of SPG11-dNeurons and spatacsin-silenced mouse neurons.
This approach is based on the commonly accepted assumption that orthologs genes derived by speciation are more likely to share a common function, in contrast to paralogs genes derived by gene duplication which are expected to diverge functionally over time [ 1, 2].
Functionally, this time delay in FIH-release can prevent a premature FIH-release during a brief and perhaps only transient reoxygenation event, and only sustained reoxygenation will trigger bulk FIH-release.
For the first time, functionally graded carbon nanofiber/phenolic nanocomposites were designed and fabricated.
The two control objectives can be integrated because they are functionally separated by time scale.
They were uncovered at 6 weeks at which time functionally loaded screw-retained provisional crown was delivered per a FDA approved protocol for this implant system.
Cell lines kept in culture can functionally evolve over time to no longer represent the original cell line (reviewed in [23]).
We focused on two phenotypic traits that are not functionally linked: flowering time and perception of symbiotic microbes.
In the absence of p21, normal haematopoietic stem cells as well as transformed leukaemic stem cells functionally exhaust over time.
It is thought that homeologues do pair at meiosis in recent autopolyploids, but that most stable polyploid taxa become functionally diploid over time, meaning that gene copies from different ancestral genomes do not recombine [ 47].
In summary, we have developed a novel method for using histone modification-directed ChIP-Seq to reveal dynamic nucleosome occupancy and position and describe, for the first time, functionally distinct modes of nucleosome remodeling upon chromatin binding by GR.
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