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However, these partially mature DCs were functionally susceptible to rh-HMGB1 as shown by the increased release of the chemokines, MCP1, MIP-1α, MIP-1β and IL-8 by hr-HMGB1-treated DCs (Fig. 3c).
Thus all heterozygotes (RS) are functionally susceptible and only homozygous resistant insects can survive on Cry2Ab toxin.
Ideally transgenic plants would produce toxin at concentrations that were several times greater than those which kill susceptible insects, to render heterozygotes functionally susceptible (Gould 1998).
The offspring of such matings will be heterozygous and thus functionally susceptible to a high-dose of Bt toxin (Gould 1998).
In rRNA, sites that are functionally susceptible to deleterious substitutions, metal ion-mediated cleavage, or structural modifications are clustered in domains V and VI, within the functional core of the ribosome.
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Thus, these data suggest that athero-susceptible DMRs functionally associate with gene regulation at the level of the 5' UTR and individual gene/exons, consistent with a contribution to the heterogeneity of endothelia in diverse chemical and physical environments.
Circulating Tfh and Th2 cells were the least susceptible among the functionally distinct T cell subsets to in vitro MV infection19.
These annotation-based clusters suggest that functionally different genes expressed in susceptible fields of the lungs eventually contribute to the formation of either fibrosis or emphysema, depending on the pattern of gene expression in that field.
Moreover, the observation that CRPC cells like 22Rv1 or LNCaP-SSR, expressing either constitutively active AR-Vs or functionally deregulated full length AR, are more susceptible to the effects of JS-K than LNCaP cells further supports this assumption.
Furthermore, using high doses of pesticides makes resistance alleles functionally recessive, such that heterozygotes harbouring both resistant and susceptible alleles experience mortality as severely as susceptible homozygotes.
Recently, Jian and colleagues have shown that the anti-oxidant response element nuclear factor E2 protects melanocytes from H2O2 damage through the induction of antioxidant genes, such as heme oxygenase-1, and that this pathway is functionally deficient in vitiligo melanocytes, rendering them more susceptible to oxidative stress [76, 77].
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