A simple proteomic approach designed to assess the metabolic phenotype of cancer, i.e., its bioenergetic signature, molecularly and functionally supports Warburg's hypothesis.
Transcriptome analysis of PDAC organoids revealed gene-expression signatures that associated Wnt niche subtypes with GATA6-dependent gene expression subtypes, which were functionally supported by genetic perturbation of GATA6.
With respect to the ALL datasets, we found that empirical Bayes statistics was the most biologically (functionally) supported method for the ALL1, ALL3 and ALL4 datasets.
The selected candidate genes originate from linkage regions predicted to genetically interact, and are functionally supported by evidence for physical interaction at the level of protein complexes.
In a previous assessment of the rat DIA1 gene product, the presence of a predicted signal peptide was detected, and functionally supported by localization of DIA1 to the lumen of the Golgi apparatus [62].
Thus, our study suggests that antibody- and NK-based immunotherapies are functionally supported by monocytes in ovarian cancer.
This functionally supports the hypothesis that TSE represents a general repression mechanism which can be co-opted by new transposable elements to regulate their activity after a transfer to the D. melanogaster genome.
Our model that the HLE of one RNase monomer contributes to RNA cleavage by the catalytic center of a different RNase monomer is functionally supported by the in trans complementation assay described above.
Accordingly, the selective ATM inhibitor KU-55933 markedly reduces the AMPKα-activating effects of metformin in rat hepatoma cells, functionally supporting the first genome-wide association study that unexpectedly found the ATM gene as the causal modulator of glycemic responsiveness to metformin among type 2 diabetic patients [ 8].
To this end, we develop an experimental system based on two functionally different support cells differing in their ability to support the development of B-lineage cells from immature hematopoietic progenitor cells.
