Sentence examples for functionally substitute from inspiring English sources

Interestingly, human TLK2 could functionally substitute for tlk-1, suggesting that the mitotic roles of TLK members might be evolutionarily conserved.

To identify genes that can functionally substitute for oncogenic RAS, we systematically expressed 15,294 open reading frames in a human KRAS-dependent colon cancer cell line engineered to express an inducible KRAS-specific shRNA.

And we further considered the potential influence of alternative cellular roles for Clock such as the transcription factor neuronal PAS domain protein 2 NPAS2 (MOP4), which was able to functionally substitute for the loss of Clock in the SCN but not in peripheral tissues in mice to regulate circadian rhythmicity (DeBruyne et al., 2007a, b; Debruyne, 2008).

Retrogenes are supposed to functionally substitute their X-linked transcriptionally silenced parental genes.

Our results suggested that DKK2 could not functionally substitute for DKK1 tumor-suppressive effect in EFT.

All three can functionally substitute for loss of their yeast orthologues in S. cerevisiae.

We next tested whether three C. elegans DNase II homologues can functionally substitute for one another.

Both Sp1 and Sp4 recognize the same DNA binding sequence, and functionally substitute with each other in vitro [2].

LmrA can functionally substitute for ABCB1 in human lung fibroblasts, and exhibits a substrate specificity similar to that of the human protein [12].

Mel18 is a component of a PRC1-like complex capable of H2AK119 monoubiquitination and can functionally substitute for Bmi1 in many situations [37].

We therefore transformed this strain with the different RNP-GFP fusions in order to determine whether these could functionally substitute for Lhp1.